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Home sales fell again in September as surging mortgage rates, rising prices discouraged homebuyers_我的网站

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一 | LOS ANGELES -- Sales of previously occupied U.S. homes fell for the fourth month in a row in September, held back by surging mortgage rates and a thin supply of properties on the market.Existing home sales fell 2% last month from August to a seasonally adjusted annual rate of 3.96 million, the National Association of Realtors said Thursday. That’s just above the 3.9 million unit pace that economists were expecting, according to FactSet.Sales sank 15.4% compared with the same month last year and are down 21% through the first nine months of the year versus the same period in 2022.Despite the housing market slump, home prices kept climbing versus a year ago. The national median sales price rose 2.8% from September last year to $394,300. It slipped 3.1% from August.“Clearly, the story of limited inventory and rising and rising mortgage rates continues to hinder the home sales market,” said Lawrence Yun, the NAR’s chief economist.The weekly average rate on a 30-year mortgage moved above 7% in August, when many of the home sales that were finalized in September would have gone under contract. It has remained above that threshold since, surging last week to 7.57%, the highest level since 2000, according to mortgage buyer Freddie Mac.High rates can add hundreds of dollars a month in costs for borrowers, limiting how much they can afford in a market already out of reach for many Americans. They also discourage homeowners who locked in rock-bottom rates two years ago from selling.While surging mortgage rates have shut out many prospective buyers, a chronic shortage of homes for sale continues to keep the market competitive, especially for the most affordable homes.Homes sold last month typically within just 21 days after hitting the market, and about 26% of homes sold for more than their list price, the NAR said.All told, there were 1.13 million homes on the market by the end of last month, up 2.7% from August, but down 8.1% from September last year, the NAR said. That amounts to just a 3.4-month supply, going by the current sales pace. In a more balanced market between buyers and sellers, there is a 4- to 5-month supply.。

二 | 这种新的分子癌症治疗方法依赖于一种特定的分子，它可以寻找围绕癌细胞的酸性环境。

三 | 但是，为了使细胞有足够的酸性，它们不能是“冷”的肿瘤，这种肿瘤几乎没有免疫活性。

四 | 这就是被称为STING激动剂的药物发挥作用的地方。这些药物使肿瘤“燃烧”起来，允许免疫系统对其作出反应。

五 | 然而，找到"冷"癌细胞可能很困难。这就是新的分子癌症疗法发挥作用的地方。研究人员本月在《肿瘤学前沿》（Frontiers of Oncology）杂志上发表了一项关于该分子的研究。根据该研究，该分子被称为pH值低的插入肽（pHLIP），它被吸引到酸性环境。通过使用该分子引导药物到肿瘤和癌细胞，他们能够将它们踢出"寒冷"的肿瘤范围，推动免疫系统进行反击。然后，他们可以使用免疫检查点抑制剂来有效地移除使免疫系统不至于用力过猛的自然刹车。这种分子癌症治疗方法让免疫系统更长时间地对抗癌症。

六 | 这是一个双重的系统，基本上允许研究人员准确地引导药物到它们需要的地方。近年来，我们已经看到越来越多像这种新的分子癌症治疗方法这样的靶向选择出现了。一种针对癌细胞的病毒也一直在进行，我们甚至看到研究人员在测试一种能杀死皮肤癌的凝胶。在测试分子癌症治疗方法时，研究人员将pHLIP与STING激动剂耦合在一起，然后对20只患有结肠直肠肿瘤的小鼠进行治疗。他们发现，在一次注射后，18只小鼠的肿瘤在几天内完全消失。在另一组有较大肿瘤的小鼠中，他们看到接受治疗的10只小鼠中有7只肿瘤消失了。